Complex regional pain syndrome: what causes this disease?

The chronic pain can be mild and of high intensity and there are few forms of chronic pain which last longer than six months. The complex regional pain syndrome is one of such forms of chronic pain. This pains effects only one limb and results from injury. The disease complex regional pain syndrome is known as CRSP as well which can be triggered by the failure of the central and nervous system. The nervous system is based on the brain cords and spinal cords and the process of the brain sending signals to the spinal cord and all other parts is known as the peripheral nervous system. The prolonged pain to any limb such as arm, hand, foot or leg can be a symptom of this disease.

This syndrome is divided into two types CRPS-I and CRPS-II. The CRPS-I is related to those patients whose nerve injury is doubtful, however, CRPS-II when the lab reports diagnose the nerve injury and there is no doubt left. Both CRPS-I and CRPS-II were being recognized with different terms in the past. The CRPS-I was known as reflex sympathetic dystrophy syndrome, however, the term which was being used by the CRPS-II causalgia.

Causes and symptoms of Complex regional pain syndrome

There are at least 5% of people in every 100,000 people who are at the risk of facing this disease and the ratio of the vulnerable is increasing day by day. At least half of the cases of CRSP are not being even diagnosed which has motivated the medical authorities around the world to increase awareness about Complex regional pain syndrome. However, it is also a fact if a doctor successfully diagnoses CSPR within the first three months, the chances of recovery of the patient’s increases. The population of USA is more vulnerable to CRSP but the worst fact is that more than half of patients remained undiagnosed for longer which reduce their recovery time. The reason which makes the disease hard to diagnose is that it is linked with various types of abnormalities including serum autoantibodies, limb-confined inflammation, sympathetic dysregulation, tissue hypoxia, and there is also the small fiber damage. This made it confusing for doctors to understand whether they should treat the patient with pain medication or suggest treatments for neurology or rheumatology. However, science has advanced enough in the last 2 decades to find suitable diagnostic systems which have increased the ratio of diagnoses of disease. The causes for this disease are not specific, however, they are known to be genetic and rare. However, some undefined symptoms related to the disease change in skin color and texture. It causes a little bit of shine on the affected area and also makes it thinner than it usually is. In this condition, the elements like thinly myelinated sensory nerve fibers which are also known as axons send blood vessels the pain messages.

Suggested medication and treatments

Most of the doctors suggest anti-depressants to relieve patients from severe pain for short time periods. There is pain relieving medication which does not work in many cases. Doctors also give medicines like intravenous immunoglobulin and intravenous anesthetics to the patients. There is some bone-loss medication which doctors suggest to the patients of Complex regional pain syndrome. The most conventional procedure to treat CRSP is regional sympathetic nerve block, however, there are others which include tender point injectors, spinal cord stimulation, and many others.

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